1. inner conflicts with record company, and them not wanting to promote him
2. eminem's hiatus hurt shady/aftermath, including 50 cent
3. he was more about style and image rather than lyrics
4. GRoDT set a standard so high, 50 cent himself couldnt meet it
5. 50 literally represented the mood of the early 2000's crunk/thug era, making him less welcome in the late 2000's fresh/swag era.
6. 50 cent's material after GRoDT was declining in quality, imo
7. his many beefs with over a dozen artists eventually got to him
8. new york is competitive rap scene. it's hard to stay on top for a while